Products and methods for controlling the suppression of the neoplastic phenotype
AssigneeThe Regents of the University of California
InventorsWen-Hwa Lee, Huei-Jen Su Huang, Eva Y. H. P. Lee
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Abstract
A method for gene therapy for cancers wherein chromosomal location of an inactive or defective cancer suppressing gene is established, a replacement gene which is preferably cloned is then used to replace the inactive or defective cancer suppressing gene in the chromosome. In addition to its uses in therapy, the present invention provides a means for prophylactically treating individuals having a genetic predisposition to cancer and provides an animal model for testing for carcinogenicity of environmental substances.
Claims6
An isolated nucleic acid molecule comprising a nucleotide sequence encoding a full length human wild type RB protein, as shown in FIG. 6.
An isolated nucleic acid vector suitable for transfecting mammalian cancer cells, the vector comprising transcription regulatory sequences operably linked to a nucleotide sequence encoding a full length human wild type RB protein, as shown in FIG. 6.
Dependencies are inferred from the claim text.