Ermophilane sesquiterpenoids as HIV intergrase inhibitors

A compound of molecular formula C.sub.25 H.sub.34 O.sub.6 and having the following properties:

• (a) the .sup.13 CNMR chemical shifts as measured in CDCl.sub.3 at 25.degree. C. at 100 MHz:196.85, 193.13, 177.87, 166.78, 158.90, 149.69, 147.66, 136.47, 129.60, 125.83, 72.65, 53.31, 43.18, 43.08, 38.28, 36.53, 33.34, 29.77, 29.66, 22.78, 20.12, 19.98, 19.53, 14.08, 12.65;
• (b) .sup.1 HNMR chemical shifts as measured in CDCl.sub.3 at 25.degree. C. at 400 MHz:
• 9.54(s), 6.54 (dq, 10, J=1.2), 6.35(s), 6.25(s), 6.10(s), 5.25 (t, J=2.8), 2.46 (dd, J=13.2, 3.2), 2.26 (t, J=13.6), 2.12 (dd, J=13.2, 4.0), 3.73 (dd, J=14.8, 4.4), 1.4 (m), 1.3 (m), 2.50(m), 2.15 (m), 1.7 (m), 1.2 (m), 1.3 (m), 2.3 (m), 1.9 (m), 1.00 (d, J=6.6), 1.50 (s), 0.87 (t, 7.2), 1.80 (d, 1.6);
• (c) an ultraviolet absorption spectrum in methanol which exhibits absorption maximum at 220 nm, and
• (d) an optical rotation of ›.alpha.!.sup.25 D=+38.3.