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US 5,858,716 AGranted
H2CAA71 polynucleotides
AssigneeSmithKline Beecham Corporation
InventorsNabil A. Elshourbagy, Xiaotong Li, Derk J. Bergsma
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AssigneeSmithKline Beecham Corporation
InventorsNabil A. Elshourbagy, Xiaotong Li, Derk J. Bergsma
Estimating the term…
Novel 7TM receptor (H2CAA71) polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Novel 7TM receptor (H2CAA71) polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthna; Parkion's disease; acute heart failure; hypotension; hypertension; uinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
An isolated polynucleotide comprising a nucleotide sequence encoding the polypeptide having the amino acid sequence set forth in SEQ ID NO 2.
An isolated polynucleotide obtainable by screening an appropriate library under stringent hybridization conditions with a probe having the sequence of a polynucleotide encoding the polypeptide set forth in SEQ ID NO:2 wherein said isolated polynucleotide encodes a human H2CAA71 protein.
An isolated probe comprising a nucleotide sequence encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:2 wherein the nucleotide sequence comprise up to a total of 5 nucleotide alterations, wherein said alterations include deletions, substitutions, or insertions for each 100 nucleotides of the nucleotide sequence.
An isolated polynucleotide comprising a nucleotide sequence which is the entire coding region of the polynucleotide sequence set forth in SEQ ID NO:1.
An isolated polynucleotide comprising the polynucleotide sequence set forth in SEQ ID NO:1.
An expression vector comprising a nucleic acid encoding a polypeptide comprising the amino acid sequence set forth in SEQ ID NO:2.
Dependencies are inferred from the claim text.