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US 5,858,713 AGranted
Calcium permeable insect sodium channels and use thereof
AssigneeCornell Research Foundation, Inc.
InventorsDavid M. Soderlund, Patricia J. Ingles
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AssigneeCornell Research Foundation, Inc.
InventorsDavid M. Soderlund, Patricia J. Ingles
Estimating the term…
The present invention is directed to isolated nucleic acid molecules encoding a voltage-sensitive sodium channel (VSSC) of an insect having a mutation therein which renders the sodium channel permeable to calcium, as well as to the isolated calcium permeable voltage-sensitive sodium channels encoded thereby. Nucleic acid molecules encoding calcium permeable VSSCs of Musca domestica, Drosophila melanogaster, and Heliothis virescens are specifically provided. These calcium permeable channels can be used to monitor the function of the channel by monitoring calcium transport through the sodium channel, and for screening chemical agents for the ability of the chemical agent to modify sodium channel function, again by monitoring calcium transport through the channel.
An isolated nucleic acid molecule encoding a voltage-sensitive sodium channel of an insect having a mutation therein which renders the sodium channel encoded by said nucleic acid molecule permeable to calcium.
An isolated nucleic acid molecule encoding a calcium permeable voltage-sensitive sodium channel of an insect, said nucleic acid molecule encoding an amino acid sequence selected from the group consisting of:
Dependencies are inferred from the claim text.