Fibronectin binding protein B compounds
AssigneeSmithKline Beecham Corporation
InventorsJohn Edward Hodgson, Martin Karl Russell Burnham
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AssigneeSmithKline Beecham Corporation
InventorsJohn Edward Hodgson, Martin Karl Russell Burnham
Estimating the term…
Novel fibronectin binding protein B polypeptides and DNA (RNA) encoding such novel fibronectin binding protein B and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such novel fibronectin binding protein B for the treatment of infection, particularly bacterial infections. Antagonists against such novel fibronectin binding protein B and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of novel fibronectin binding protein B nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding novel fibronectin binding protein B family and for detecting the polypeptide in a host.
An isolated polynucleotide comprising a member selected from the group consisting of:
An isolated polynucleotide comprising a member selected from the group consisting of:
An isolated polynucleotide consisting of nucleotides 1 to 558 set forth in SEQ ID NO:2.
An isolated polynucleotide that encodes a polypeptide having amino acids 1 to 186 set forth in SEQ ID NO:1 of fibronectin binding protein B of Staphylococcus aureus strain WCUH29.
Dependencies are inferred from the claim text.