Polynucleotides encoding human DNA ligase III and methods of using these polynucleotides
AssigneeHuman Genome Sciences, Inc.
InventorsYing-Fei Wei, Guo-Liang Yu, William A. Haseltine
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Abstract
A human DNA Ligase III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptide via gene therapy for the treatment of disorders associated with a defect in DNA Ligase III. Antagonists against such polypeptides and their use as a therapeutic to destroy unwanted cells are also disclosed. Diagnostic assays to detect mutant DNA Ligase III genes are also disclosed.
Claims19
An isolated polynucleotide comprising a polynucleotide having at least 95% identity to a member selected from the group consisting of:
- (a) a polynucleotide encoding a polypeptide comprising the amino acid sequence from amino acid 2 to 922 of SEQ ID NO:2;
- and
- (b) the complement of (a).
An isolated polynucleotide comprising a polynucleotide having at least a 95% identity to a member selected from the group consisting of:
- (a) a polynucleotide encoding the same mature polypeptide encoded by the human cDNA in ATCC Deposit No. 97052;
- and
- (b) the complement of (a).
Dependencies are inferred from the claim text.