Method for detecting allergy
AssigneeOy Aboatech AB
InventorsEsa-Matti Lilius, Erika Isolauri, Seppo Salminen
Life of this patent
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Abstract
The present invention comprises a simple way of identifying the tendency towards allergy or allergy already broken out, and showing the probability of allergy in a patient, by measuring the receptor expression of the phagocytic cells of peripheral blood. With a logistic regression model a combination of variables were found which best describe the probability of allergy. Thus the invention relates to a method for detecting allergy and a test kit for accomplishing the method. The invention also relates to a sensitive and specific logistic model for determining the probability of allergy.
Claims18
A method for detecting allergy comprising:
- (a) collecting a blood sample from a patient;
- (b) determining in the blood sample complement receptor 1 (CR1) and/or complement receptor 3 (CR3) expression of phagocytic cells;
- (c) further determining Fc.gamma.I receptor expression in said cells;
- (d) comparing the CR1 and/or CR3 receptor expression values obtained to corresponding average values of healthy individuals;
- and
- (e) comparing the Fc.gamma.I receptor expression value obtained to corresponding average values of patients with an acute viral or bacterial infection, wherein elevated CR1 and CR3 values and a reduced Fc.gamma.I receptor expression value indicate the presence of allergy.
A method for determining a probability of allergy in a patient which has been sensitized to an antigen, comprising:
- a) determining CR1 receptor expression in neutrophils of a blood sample collected from the patient;
- b) determining Fc.gamma.I and Fc.gamma.II receptor expressions in monocytes of said blood sample;
- and
- c) comparing values obtained for the expression of CR1, Fc.gamma.I and Fc.gamma.I receptors with those of healthy individuals, wherein an elevated CR1 receptor expression on neutrophils and a reduced Fc.gamma.I/Fc.gamma.II receptor expression ratio in monocytes indicate the probability of allergy.
A method for detecting allergy in a patient having at least one symptom of allergy, comprising:
- a) determining the CR1 receptor expression in neutrophils of a blood sample collected from the patient;
- b) determining the Fc.gamma.I and Fc.gamma.II receptor expressions in monocytes of said blood sample;
- and
- c) comparing the values obtained with those of healthy individuals, an elevated CR1 receptor expression on neutrophils and a reduced Fc.gamma.I/Fc.gamma.II receptor expression ratio in monocytes indicates the existence of allergy.
Dependencies are inferred from the claim text.