Method of screening calcium receptor-active molecules

A method of screening for a compound able to affect one or more activities of a calcium receptor comprising the steps of,

• a) contacting a recombinant cell with a test compound, wherein said recombinant cell comprises a recombinant nucleic acid expressing said calcium receptor, provided that said cell does not have functional calcium receptor expression from endogenous nucleic acid, and
• b) determining the ability of said test compound to affect one or more activities of said calcium receptor, and comparing said ability with the ability of said test compound to affect said one or more calcium receptor activities in a cell not comprising said recombinant nucleic acid;
• wherein said recombinant nucleic acid comprises a calcium receptor nucleic acid selected from the group consisting of:
• a) nucleic acid of SEQ ID NO 1,
• b) nucleic acid of SEQ ID NO 2,
• c) nucleic acid of SEQ ID NO 3,
• d) nucleic acid of SEQ ID NO 4,
• e) nucleic acid encoding the amino acid of SEQ ID NO 5,
• f) nucleic acid encoding the amino acid of SEQ ID NO 6,
• g) nucleic acid encoding the amino acid of SEQ ID NO 7,
• h) nucleic acid encoding the amino acid of SEQ ID NO 8, and
• i) a derivative thereof encoding said calcium receptor, wherein said derivative encodes a receptor having one or more activities of said calcium receptor and comprises at least 20 contiguous nucleotides which can hybridize under stringent hybridization conditions to a complement of at least 20 contiguous nucleotides of the calcium receptor nucleic acid of any of (a), (b), (c), (d), (e), (f), (g), and (h).