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US 5,858,655 AGranted
Method for diagnosing neoplasia by detecting expression of PRAD1 cyclin
AssigneeThe General Hospital Corporation
InventorAndrew Arnold
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Abstract
A novel cyclin, termed prad1, is disclosed, along with the nucleic acid sequence that encodes human prad1. Antibodies that bind specifically to prad1 and cell lines and transgenic animals containing DNA that encodes prad1 are also disclosed. In addition, methods of using the antibodies or fragments of the nucleic acid sequence, for example, to diagnose a neoplastic condition by detecting expression of prad1 or to modulate cellular proliferation, are disclosed.
Claims7
A method for diagnosing neoplasia by detecting expression level of PRAD1 cyclin comprising:
- obtaining a nucleic acid sample from an animal suspected of having a neoplastic condition;
- contacting said nucleic acid sample with a single-stranded DNA comprising a segment of a PRAD 1 at least 8 nucleotides in length, said Prad1being the Prad1homolog of the species to which said animal belongs;
- and
- detecting the level of hybridization of said single-stranded DNA with said nucleic acid sample, said level being diagnostic for said neoplastic condition.
1 more element
Dependencies are inferred from the claim text.