Red blood cell composition containing vitamin E or derivatives thereof which exhibits reduced potassium ion leakage after a photoinactivation process
AssigneeNew York Blood Center, Inc.
InventorsEhud Ben-Hur, Shanti Rywkin, Bernard Horowitz
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Abstract
A red blood cell containing composition is presented which has reduced potassium ion leakage after irradiation in a virus photoinactivation process. The irradiated red blood cell containing composition comprises red blood cells, a photosensitizer, and sufficient vitamin E or derivatives thereof to prevent potassium leakage. Preferred photosensitizers are aluminum phthalocyanines, AlPcS.sub.4 or Pc5. A preferred vitamin E derivative is Trolox.
Claims8
An irradiated red blood cell-containing composition comprising red blood cells, a photosensitizer, and vitamin E or a derivative thereof, wherein the concentration of the vitamin E or derivative thereof is in an amount effective to reduce leakage of K.sup.+ from red blood cells undergoing photoinactivation in the presence of a photosensitizer.
Dependencies are inferred from the claim text.