Hydrolyzed cellulose granulations for pharmaceuticals
AssigneeFMC Corporation
InventorsMarc S. Karetny, David F. Erkoboni, Ronald S. Vladyka, Jr., Howard J. Stamato
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Abstract
The present invention provides a method for preparing a spray-dried compressible granular formulation for preparing pharmaceutical tablets in which hydrolyzed cellulose is used as a granulation aid, the resulting granulations, and pharmaceutical tablets compressed from such granules. In these formulations there is employed from 1 to 97% by weight pharmaceutical active, from about 3 to 99% by weight hydrolyzed cellulose, based on the dry weight of the granulation, and optionally conventional granulation and/or tableting additives such as surfactants, disintegrants and antiadherents/flow aids.
Claims7
A substantially porous spherical granular composition for compression into pharmaceutical tablets consisting essentially of 1 percent to 97 percent by weight of pharmaceutical active agent and 3 percent to 99 percent by weight of hydrolyzed cellulose.
Dependencies are inferred from the claim text.