Liposomal formulations of mitoxantrone
AssigneeThe University of British Columbia
InventorsHoward J. Lim, Thomas D. Madden, Marcel B. Bally, Lana W. Barber, Charmaine W. Chang
Life of this patent
Estimating the term…
Abstract
Compositions and methods which are useful for the treatment of solid tumors in a host and which are also useful for increasing the therapeutic index of mitoxantrone in a host. The pharmaceutical compositions are liposomal formulations of mitoxantrone in which the liposomes comprise a mixture of cholesterol and a diacylphosphatidylcholine, preferably 1,2-sn-dimyristoyl-phosphatidylcholine.
Claims10
A pharmaceutical composition for the treatment of solid tumors, comprising a liposomal formulation of mitoxantrone, said liposomes consisting essentially of a mixture of about 30% to about 50% cholesterol and about 50% to about 70% 1,2-sn-dimyristoylphosphatidylcholine and said mitoxantrone being encapsulated in the aqueous interior of said liposomes.
A method for increasing the therapeutic index of mitoxantrone in a patient, said method comprising,
- (i) encapsulating mitoxantrone in liposomes comprising a mixture of cholesterol and 1,2-sn-dimyristoylphosphatidylcholine to provide a liposomal formulation;
- and
- (ii) administering said liposomal formulation to said patient, whereby said therapeutic index of mitoxantrone is improved relative to non-liposomal formulations of mitoxantrone.
Dependencies are inferred from the claim text.