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US 5,858,388 AGranted
Subcutaneous implant for delivery of hydromorphone
AssigneeAxxia Technologies
InventorsStuart A. Grossman, Kam W. Leong, Glenn J. Lesser, Hungnan Lo
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Abstract
A non-abusable, non-inflammatory, biocompatible, non-biodegradable, subcutaneous, polymeric implant for the prolonged, controlled release of hydromorphone with near zero-order kinetics is described. Methods of alleviating cancer pain and treating opioid drug addiction with the implant are also described.
Claims18
A subcutaneous delivery system comprising:
- i) a matrix comprising poly(ethylene-vinyl acetate),
- ii) hydromorphone embedded homogeneously in said matrix,
- iii) a biocompatible, non-biodegradable, polymer coating said matrix,
- wherein said delivery system is adapted to deliver said hydromorphone at a rate of plus or minus 500% of the target delivery, wherein said polymer is hydromorphone impermeable in subcutaneous use, and wherein said delivery system has a geometry such that there is an external coated wall and an internal uncoated wall forming an opening for release of said hydromorphone and the distance between the uncoated wall and the coated wall opposite the uncoated wall is substantially constant throughout the delivery system.
1 more element
A subcutaneous delivery system comprising:
- i) a matrix comprising polyethylene vinyl (acetate),
- ii) hydromorphone embedded homogeneously in said matrix, and
- iii) a biocompatible, non-biodegradable, polymer coating surrounding said matrix
- wherein said delivery system is cylindrical in shape and has a cylindrical shaped opening along the axis of said delivery system forming an internal uncoated wall in said delivery system for release of said hydromorphone, wherein said polymer is hydromorphone impermeable in subcutaneous use, and wherein said delivery system is adapted to deliver said hydromorphone at a rate of plus or minus 500% of the target delivery.
1 more element
Dependencies are inferred from the claim text.