Pharmaceutical compositions containing D.sub.2 O
AssigneeMedeva Europe Limited
InventorsIan George Stephen Furminger, Philip James Sizer
Life of this patent
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Abstract
A pharmaceutical composition comprises a solution or suspension of a biological agent in a diluent comprising D.sub.2 O, which solution or suspension contains sufficient amounts of a sugar, phosphate, glutamic acid or a physiologically acceptable salt thereof and, optionally, a non-toxic protein, a peptone or a mixture of two or more amino acids besides glutamic acid to enhance the stability of the agent. Typically, the composition is a suspension of a live attenuated poliovirus or an inactivated poliovirus of each of poliovirus types 1, 2 and 3. Preferably the solution or suspension contains stabilising amounts of sucrose, KH.sub.2 PO.sub.4, K.sub.2 HPO.sub.4, L-glutamic acid or sodium glutamate and human serum albumin (SPGA).
Claims12
A vaccine which comprises a suspension of a virus in a diluent, wherein the diluet comprises
- (1) D.sub.2 O as the principal component and
- (2) (a) a sugar, (b) phosphate, (c) glutamic acid or a physiologically acceptable salt thereof, and optionally (d) a non-toxic protein, a peptone or a mixture of two or more amino acids besides glutamic acid,
- components (1) and (2) being present in amounts that enhance the stability of the virus.
A process for the preparation of a vaccine, which process comprises forming a suspension of a virus in a diluent comprising
- (1) D.sub.2 O as the principal component and
- (2) (a) sugar, (b) phosphate, (c) glutamic acid or a physiologically acceptable salt thereof, and optionally (d) a non-toxic protein, a peptone or a mixture of two or more amino acids besides glutamic acid,
- components (1) and (2) being present in amounts that enhance the stability of the virus.
Dependencies are inferred from the claim text.