Immunogenic peptides, antibodies and uses thereof relating to CD4 receptor binding
AssigneeDana-Farber Cancer Institute, Inc.
InventorsJoseph G. Sodroski, William A. Haseltine, Udy Olshevsky, Eirik Helseth, Craig D. Furman
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Abstract
Immunogenic peptides containing amino acid residues which define a binding site to a CD4 receptor are disclosed. Antibodies to these peptides are also disclosed. Methods of reducing the ability of a gp12O env protein to bind to CD4 are also disclosed. Methods of treatment and prophylaxis using these antibodies and peptides are also described.
Claims8
An immunogenic gp120 polypeptide from HIV-1, HIV-2 or SIV comprising conserved regions which have at least one of variable regions V1, V2 or V3 deleted and replaced by a linker sequence, wherein the linker sequence comprises amino acids that maintain the overall 3-dimensional structure of gp120 by permitting turns in the tertiary structure.
Dependencies are inferred from the claim text.