Prilocaine and hydrofluorocarbon aerosol preparations
OwnerRichard A. Henryinventor
Life of this patent
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Abstract
Prilocaine base, in liquid and micro rod crystal form, can be solubilized within hydrofluorocarbon propellants to produce a stable, oily liquid. The prilocaine base can be used to solubilize additional medicaments within hydrofluorocarbon propellants that are not ordinarily soluble. The combination of prilocaine base and hydrofluorocarbon propellant can be used as an aerosolized spray to provide topical anesthesia.
Claims5
An aerosol composition, consisting essentially of 1-99% of a hydrofluorocarbon propellant selected from the group consisting of 1,1,1,2-tetrafluoroethane and 1,1,1,2,3,3,3-heptafluoropropane, and combinations thereof and 1-99% of a prilocaine base solubilized within said hydrofluorocarbon propellant.
An aerosol composition for anesthetizing a mammal, comprising:
- 1-99% wt of hydrofluorocarbon propellant selected from the group consisting of 1,1,1,2-tetrafluoroethane and 1,1,1,2,3,3,3-heptafluoropropane, and combinations thereof, said hydrofluorocarbon propellant being the sole propellant in said aerosol composition;
- 1-99% wt prilocaine base solubilized within said hydrofluorocarbon propellant;
- and
- 0.01-99% wt of pharmaceutical other than prilocaine.
A method of solubilizing or suspending medicaments in hydrofluorocarbon propellants to form an aerosol composition for delivery to a mammal, comprising the steps of:
- dissolving 1-99% wt prilocaine base in 1-99 % wt of a hydrofluorocarbon propellant selected from the group consisting of 1,1,1,2-tetrafluoroethane and 1,1,1,2,3,3,3-heptafluoropropane, and combinations thereof;
- and
- incorporating 0.01-99% wt of a medicament other than prilocaine.
Dependencies are inferred from the claim text.