Capillary electrophoresis-mass spectrometry interface
AssigneeCornell Research Foundation, Inc.
InventorsJack D. Henion, Robin L. Sheppard, Timothy Wachs
Life of this patent
Estimating the term…
Abstract
An interface for connecting an electrophoresis capillary to a mass spectrometer sprayer tube includes a first length of support tubing having an axial bore receiving and aligning the capillary and tube in end-abutting relationship at a junction. A solvent tube in a second length of support tubing intersects the first length of tubing in a T at the junction to supply makeup solvent to analyte flowing from the capillary to the sprayer tube. The tubing is secured in a T fitting which seals the tubing around the capillary, the sprayer tube, and the solvent tube.
Claims16
A liquid junction, comprising:
- a fitting;
- a support tube having an axial bore extending through said fitting, said support tube bore having an entrance end for receiving an entry tube and an exit end for receiving an exit tube;
- a window in said support tube intersecting said axial bore within said fitting;
- and
- a make-up tube in said fitting, said make-up tube having an axis which intersects said first axial bore at said window, said support tube serving to align said entry and exit tubes in end to end relationship at a junction within said axial bore and in said window, said make-up tube terminating at said window.
A liquid junction, comprising:
- a T fitting having a top arm and an intersecting leg, said top arm and said intersecting leg having respective axial bores;
- a support tube having a longitudinal axis, an entrance end and an exit end, said support tube extending through said top arm axial bore;
- a liquid supply tube located in said entrance end of said support tube;
- a liquid outlet tube located in said exit end of said support tube, said supply tube and said outlet tube meeting in end-to-end relationship at a junction within said support tube and being axially aligned by said support tube;
- a window in said support tube at said junction;
- and
- a fluid supply tube having a longitudinal axis and extending into said axial bore of said intersecting leg of said T fitting, said axis of said fluid supply tube intersecting said axis of said support tube at said window whereby fluid can be supplied to said junction of said liquid supply tube and said liquid outlet tube.
An interface system for interconnecting tubes, comprising:
- a first arm having first and second ends, a longitudinal axis, and a continuous axial bore:
- a second arm having first and second ends, a longitudinal axis, and a continuous axial bore, the axial bore of said second arm intersecting said axial bore of said first arm;
- a support tube in said axial bore of said first arm, said support tube including an axial bore and having an entrance end and an exit end;
- a liquid supply tube located in said support tube axial bore at said entrance end;
- a liquid outlet tube located in said support tube bore at said exit end, said liquid supply tube and said liquid outlet tube meeting in end-to-end relationship at a junction within said support tube and being axially aligned by said support tube, said junction being located at the intersection of said bores of said first and second arms;
- and
- a fluid supply tube located in said axial bore of said second arm.
Dependencies are inferred from the claim text.