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US 5,856,579 AGranted
Adduct salts of novel substituted benzylamines and a process for optically resolving them
AssigneeAjinomoto Co., Inc.
InventorsTadashi Takemoto, Toyoto Hijiya, Teruo Yonekawa
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Abstract
A process for optical resolution of a racemic substituted benzylamine is provided that involves reacting the racemic substituted benzylamine in a solvent with an optically active N-acyl-phenylalanine, -aspartic acid, or -glutamic acid, and separating the diastereomers formed by making use of the difference in the mutual solubilities of the two diastereomer salts which are generated therein.
Claims15
A process for optically resolving a substituted benzylamine comprising:
- reacting, in a solvent, a racemic substituted benzylamine selected from the group consisting of racemic .alpha.-methoxymethylbenzylamines, racemic .alpha.-(substituted phenyl)alkylamines and racemic .alpha.-(substituted phenyl)alkoxyethylamines, with an optically active N-acyl-phenylalanine, -aspartic acid, or -glutamic acid at a temperature sufficient to effect formation of two diastereomeric salts;
- and
- separating said diastereomeric salts by making use of differences in mutual solubilities of said two diastereomeric salts by selective precipitation of the less soluble of the two diastereomeric salts.
Dependencies are inferred from the claim text.