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US 5,856,571 AGranted
Semicarbazide-containing linker compounds for formation of stably-linked conjugates and methods related thereto
AssigneeCellPro, Inc.
InventorsRonald W. Berninger, Mark S. Lodge, Stanley Joseph Tarnowski, Jr.
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Abstract
Linker compounds for formation of stably-linked conjugates are disclosed. Such linker compounds are semicarbazide-containing linker compounds useful in forming conjugates having stable semicarbazone linkages. The stably-linked conjugates have utility in a variety of immunodiagnostic and separation techniques.
Claims14
A compound having the structure:
- X--(CH.sub.2).sub.n --NH--C(.dbd.R.sub.2)--NH--NH.sub.2
- wherein n=1-12;
- R2 is selected from O and NH;
- and X is selected from an animo and a protected amino group.
1 more element
A compound having the structure:
- X--(CH.sub.2).sub.n --NH--C(.dbd.R.sub.2)--NH--NH--P'
- wherein n=1-12;
- R.sub.2 is selected from O, NH and S, X is selected from an amine and a protected amine group, and P' is a protecting group.
Dependencies are inferred from the claim text.