2,2'-disubtituted 1,1'-diphosphino-ferrocenes and 1',2-disubstituted 1-phosphino-ferrocenes, processes for preparing them, their use, and transition metal complexes comprising them
AssigneeHoechst Aktiengesellschaft
InventorJoachim-Heiner Jendralla
Life of this patent
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Abstract
The present invention relates to optically active and racemic C.sub.2 -symmetric 2,2'-disubstituted 1,1'-diphosphino-ferrocenes of the formula Ia, to optically active and racemic asymmetric 1',2-disubstituted 1-phosphino-ferrocenes of the formula Ib and to achiral 2,2'-disubstituted 1,1'-diphosphino-ferrocenes of the formula II, to processes for preparing them, especially in accordance with the principle of asymmetric ortho-lithiation, to their use as ligands for transition metal complexes, to transition metal complexes comprising them, and to the use of the transition metal complexes as catalysts, especially in asymmetric syntheses. ##STR1##
Claims22
A compound of the formula I ##STR25## in which the substituents R.sup.1 are cyclohexyl, unsubstituted phenyl C.sub.6 H.sub.5 or substituted phenyl C.sub.6 H.sub.5-n R.sup.4.sub.n where n is 1 to 5 and the substituents R.sup.4 are unbranched or branched C.sub.1 - to C.sub.4 -alkyl, C.sub.1 - to C.sub.4 -alkoxy or halogen;
- the two geminal substituents R.sup.2 together are a doubly bonded oxygen atom (i.e. (R.sup.2).sub.2 is .dbd.O) or each substituent R.sup.2 on its own is hydrogen;
- the substituents R.sup.3, each on their own, are unbranched or branched C.sub.1 - to C.sub.4 -alkyl, cyclopentyl, cyclohexyl, unsubstituted phenyl C.sub.6 H.sub.5 or substituted phenyl C.sub.6 H.sub.5-n R.sup.4.sub.n, where n and R.sup.4 are as defined above under R.sup.1, or the substituents R.sup.3 are connected to one another to form a ring, in which case together they are tetramethylene --(CH.sub.2).sub.4 --, pentamethylene --(CH.sub.2).sub.5 --, 3-oxapentamethylene --(CH.sub.2).sub.2 --O--(CH.sub.2).sub.2 -- or N-methyl-3-azapentamethylene --(CH.sub.2).sub.2 --N(CH.sub.3)--(CH.sub.2).sub.2 --;
- the substituent X is hydrogen or P(R.sup.1).sub.2 ;
- or a salt thereof.
A compound of the formula II ##STR29## in which the substituents R.sup.1 are cyclohexyl, unsubstituted phenyl C.sub.6 H.sub.5 or substituted phenyl C.sub.6 H.sub.5-n R.sup.4.sub.n, where n is 1 to 5 and the substituents R.sup.4 are unbranched or branched C.sub.1 - to C.sub.4 -alkyl, C.sub.1 - to C.sub.4 -alkoxy or halogen;
- the two geminal substituents R.sup.2 together are a doubly bonded oxygen atom (i.e. (R.sup.2).sub.2 is .dbd.O) or each substituent R.sup.2 on its own is hydrogen;
- the substituents R.sup.3, each on their own, are unbranched or branched C.sub.1 - to C.sub.4 -alkyl, cyclopentyl, cyclohexyl, unsubstituted phenyl C.sub.6 H.sub.5 or substituted phenyl C.sub.6 H.sub.5-n R.sup.4.sub.n, where n and R.sup.4 are as defined above under R.sup.1, or the substituents R.sup.3 are connected to one another to form a ring, in which case together they are tetramethylene --(CH.sub.2).sub.4 --, pentamethylene --(CH.sub.2).sub.5 --, 3-oxapentamethylene --(CH.sub.2).sub.2 --O---(CH.sub.2).sub.2 -- or N-methyl-3-azapentamethylene --(CH.sub.2).sub.2 --N(CH.sub.3)--(CH.sub.2).sub.2 --;
- or a salt thereof.
Dependencies are inferred from the claim text.