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US 5,856,536 AGranted
Preparation of 19-Nor-vitamin D compounds
AssigneeWisconsin Alumni Research Foundation
InventorsHector F. Deluca, Heinrich K. Schnoes, Fariba Aria
Life of this patent
Estimating the term…
Abstract
Disclosed are 20-epi-19-nor-vitamin D compounds having the structure: ##STR1## where each of X.sub.1 and X.sub.2 independently represents hydrogen or a hydroxy-protecting group, and Z represents various known side chains.
Claims1
A 20-epi-19-nor-vitamin D compound having the structure:
- where each of X.sub.1 and X.sub.2, independently represents hydrogen or a hydroxy-protecting group, and where R is represented by the structure:
- ##STR14## where Z is selected from Y, --OY, --CH.sub.2 OY, --C.tbd.CY and --CH.dbd.CHY, where the double bond may have the cis or trans stereochemical configuration, and where Y is selected from hydrogen, methyl, --CR.sup.5 O and a radical of the structure:
- ##STR15## where m and n, independently, represent integers from 0 to 5, where R.sup.1 is selected from hydrogen, hydroxy, protected hydroxy, fluoro, trifluoromethyl, and C.sub.1-5 -alkyl, which may be straight chain or branched and, optionally, bear a hydroxy or protected-hydroxy substituent, and where each of R.sup.2, R.sup.3, and R.sup.4, independently is selected from hydrogen, fluoro, trifluoromethyl and C.sub.1-5 -alkyl, which may be straight-chain or branched, and optionally, bear a hydroxy or protected-hydroxy substituent, and where R.sup.1 and R.sup.2, taken together, represent an oxo group, or an alkylidene group, .dbd.CR.sup.2 R.sup.3, or the group --(CH.sub.2).sub.p --, where p is an integer from 2 to 5, and where R.sup.3 and R.sup.4, taken together represent an oxo group, or the group --(CH.sub.2).sub.q --, where q is an integer from 2 to 5, and where R.sup.5 represents hydrogen, hydroxy, protected hydroxy, or C.sub.1-5 alkyl.
Dependencies are inferred from the claim text.