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US 5,856,529 AGranted
Benzofuran and dihydrobenzofuran melatonergic agents
AssigneeBristol-Myers Squibb Company
InventorsJohn D. Catt, Graham Johnson, Daniel J. Keavy, Ronald J. Mattson, Michael F. Parker, Katherine S. Takaki, Joseph P. Yevich
Life of this patent
Estimating the term…
Abstract
Novel derivatives of benzofuran and dihydrobenzofuran are provided which are useful as melatonergic agents.
Claims15
A compound of Formula I or a pharmaceutically acceptable solvate thereof having the Formula:
- ##STR28## wherein Q.sup.1 and Q.sup.2 each are independently hydrogen or halogen;
- Y is CR.sup.3, CR.sup.3 R.sup.4 or (CH.sub.2).sub.n, with n=1;
- Z is oxygen and X is CH.sub.2 or CH;
- or X is oxygen and Z is CH.sub.2 or CH;
- R is hydrogen, halogen or C.sub.1-4 alkyl in both cases;
- m is 1 or 2;
- R.sup.1 is C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.1-3 haloalkyl, C.sub.1-6 alkylamino, C.sub.2-6 alkenyl, C.sub.1-4 alkoxy(C.sub.1-4)alkyl, C.sub.1-4 alkylthio(C.sub.1-4)alkyl or C.sub.1-4 trifluoromethylalkyl;
- R.sup.2 is hydrogen or C.sub.1-4 alkyl;
- and
- R.sup.3 and R.sup.4 each are independently hydrogen or C.sub.1-4 alkyl.
7 more elements
Dependencies are inferred from the claim text.