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US 5,856,511 AGranted
Synthesis of 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole and analogs thereof
AssigneeAlteon Inc.
InventorsTaikyun Rho, Michael E. Lankin, David H. Shih, Claire M. Lankin
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Abstract
The present invention relates to a practical and facile synthesis of 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole (FFI) and analogs thereof. The synthesis utilized a novel hydrazinium salt as an intermediate reaction product which facilitates the isolation of purified product in high yields.
Claims4
A process for the preparation of 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole of the formula I ##STR8## which comprises (a) reaction of a 2-haloacetyl compound of the formula II ##STR9## wherein X is chloro, bromo, or iodo;
- with 1,1-dimethylhydrazine of the formula III
- H.sub.2 N--NRR' (III)
- wherein R and R' are lower alkyl groups, to afford the compound of formula IV ##STR10## wherein R and R' are as hereinbefore defined;
- (b) reaction of the compound of formula IV with methanol at reflux temperatures to afford the desired product of formula I.
1 more element
Dependencies are inferred from the claim text.