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US 5,856,505 AGranted
Intermediates for the manufacture of dicarboxamides having thrombin inhibiting activity
AssigneeHoffmann-La Roche Inc.
InventorMilan Soukup
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Abstract
The present invention is directed to a process, and novel intermediates used in the manufacture of, dicarboxamides of the formula I ##STR1## wherein A, G, L, Q, X and Y have the meaning given in the specification, starting from corresponding N-substituted aspartic acid and from corresponding amines G-NHCH(X,Y), via corresponding N-substituted oxazolidinone and N,N-substituted aspartates.
Claims2
A compound of the formula:
- ##STR14## wherein A is a group --S(O).sub.2 R.sup.1 or --S(O).sub.2 N(R.sup.2, R.sup.3);
- R.sup.1 is naphthyl, heteroaryl, heterocyclyl, alkyl or cycloalkyl;
- and
- R.sup.2 and R.sup.3 are H, lower-alkyl, or aryl-lower alkyl, or R.sup.2 and R.sup.3, together with the N atom, form a group --N(CH.sub.2).sub.4-9 optionally interrupted by O or S.
1 more element
The compound (R)-4-carboxymethyl-3-(2-naphthalenesulfonyl)-5-oxazolidinone.
Dependencies are inferred from the claim text.