4-thia-1-azabicyclo/3.2.0/Heptane-3-Imino-2-isopropylidene-7-oxo-analogon s of beta-lactams, processes for their preparation and the use thereof
AssigneePlive, farmaceutska, kemijska, prehrambena i kozmeticka industrija, dionicko drustvo
InventorJure J. Herak
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Abstract
The object of the present invention are 4-thia-1-azabicyclo3.2.0!heptane-3-imino-2-isopropylidene-7-oxo beta-lactamic analogons of general formula I ##STR1## wherein the radicals have the following meanings: R.sup.1 is hydrogen or halogen, R.sup.2 is hydrogen, halogen, phthalimide, R.sup.3 is hydrogen, alkyl, benzyl, heterocycle e.g. isoxazole, pyrazole, 5-methyl-isoxazole-3-yl, 3,4-dimethyl-isoxazole-5-yl, 2-phenyl-pyrazole-3-yl, etc. These compounds are useful as intermediates in the preparation of novel beta-lactamic analogons or of active substances in preparations for antimicrobial therapy.
Claims13
4-Thia-1-azabicyclo3.2.0!heptane-3-imino-2-isopropylidene-7 oxo analogons of beta-lactams of the formula I ##STR4## wherein the radicals have the following meanings:
- R.sub.1 is hydrogen or halogen,
- R.sub.2 is hydrogen, halogen or phthalimide,
- R.sub.3 is hydrogen, alkyl, benzyl, isoxazole, pyrazole, 5-methyl-isoxazole-3-yl, 3,4 dimethyl-isoxazole-5-yl, or 2-phenyl-pyrazole-3-yl.
Dependencies are inferred from the claim text.