Process for preparing 1-(4-fluorophenyl)-3(R)-(3(S)-hydroxy-3-(phenyl or 4-fluorophenyl!)-propyl)-4(S)-(4-hydroxyphenyl)-2-azetidinone
AssigneeSchering Corporation
InventorBandarpalle B. Shankar
Life of this patent
Estimating the term…
Abstract
A process for preparing a compound of the formula ##STR1## wherein X is H or F, comprising: (a) alkylation of a 3-unsubstituted chiral azetidinone of the formula ##STR2## with cinnamyl bromide or 4-fluorocinnamyl bromide; (b) Wacker oxidation of the product of step (a); (c) reduction of the ketone product of step (b); and (d) debenzylation of the ketone of step (c).
Claims5
A process for preparing a compound of the formula ##STR15## wherein X is H or F, comprising (a) alkylation of the 3-unsubstituted azetidinone of the formula ##STR16## with cinnamyl bromide or 4-fluorocinnamyl bromide to obtain a compound of the formula ##STR17## (b) oxidation of the product of step (a) to obtain a compound of the formula ##STR18## (c) reduction of the ketone of step (b) to obtain a compound of the formula ##STR19## (d) debenzylation of the product of step (c).
A process for preparing a compound of the formula ##STR20## wherein X is H or F, comprising oxidation of a compound of the formula ##STR21## wherein X is H or F.
Dependencies are inferred from the claim text.