Oligonucleotides specific for hepatitis B virus
AssigneeHybridon, Inc.
InventorsBruce L. Frank, Peter C. Roberts, John Goodchild, J. Charles Craig, John S. Mills
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Abstract
The present invention discloses synthetic oligonucleotides complementary to contiguous and noncontiguous regions of the HBV RNA. Also disclosed are methods and kits for inhibiting the replication and expression of HBV, and for treating HBV infections and associated conditions.
Claims21
A synthetic oligonucleotide complementary to at least two noncontiguous regions of a hepatitis B virus (HBV) nucleic acid, the oligonucleotide being 20-30 nucleotides in length.
A synthetic oligonucleotide complementary to at least two noncontiguous regions in the epsilon region of the precore gene.
Dependencies are inferred from the claim text.