Protein affecting K.sub.ATP channels
AssigneePharmacia & Upjohn Company
InventorsVincent E. Groppi, Jr., Martin R. Deibel, Jr., Mark L. Wolfe, Anthony W. Yem
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Abstract
This invention describes the isolation and identification of a new protein, p56, useful for the identification of drugs that will selectively open or close K channels. The protein p56 has a molecular weight of about 56,000 daltons and the N-terminal peptide sequence is: Glu-Pro-Arg-Ala-Pro-Pro-Glu-Lys-Ile-Ala-Ile-Val-Gly-Ala-Gly-Ile.
Claims12
A glycoprotein of about 54,000 to 60,000 daltons, as measured by SDS PAGE gel and having a core protein mass (free of sugars) of about 51,000 daltons, as measured by SDS PAGE gel purified from rat A10 cells and capable of binding with N-(3-azido-5-iodophenyl)-N'-cyano-N"(1,1-dimethylproply)-guanidine.
A glycoprotein of about 54,000 to 60,000 daltons, as measured by SDS PAGE gel and having a core protein mass (free of sugars) of about 51,000 daltons, as measured by SDS PAGE gel purified from murine cells and capable of binding with N-(3azido-5-iodophenyl)-N'-cyano-N"(1,1-dimethylproply)-guanidine.
Dependencies are inferred from the claim text.