Antibodies specifically reactive with thrombin receptor and its components
AssigneesThe Regents of the University of California, COR Therapeutics, Inc.
InventorShaun R. Coughlin
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Abstract
The DNA encoding the cell surface receptor for thrombin has been cloned and sequenced. The availability of this DNA permits the recombinant production of thrombin receptor which can be produced at cell surfaces and is useful in assay systems both for the detection of thrombin and for the evaluation of candidate thrombin agonists and antagonists. Further, the elucidation of the structure of the thrombin receptor permits the design of agonist and antagonist compounds which are useful diagnostically and therapeutically. The availability of the thrombin receptor also permits production of antibodies specifically immunoreactive with the receptor per se or with specific regions thereof which are also useful diagnostically or therapeutically.
Claims14
An isolated antibody or fragment thereof that specifically binds a human thrombin receptor wherein said thrombin receptor has the property that it is activated by contacting it with one peptide wherein said peptide is SFLLRNPNDKYETF (SEQ ID NO:106).
An isolated antibody or fragment thereof that specifically binds the cleaved activation peptide of the human thrombin receptor, wherein said receptor has the property that it is activated by contacting it with one peptide wherein said peptide is SFLLRNPNDKYEPF (SEQ ID NO:106).
Dependencies are inferred from the claim text.