Transcripts of the MHC class I HLA-G gene and their applications
AssigneeCommissariat a l'Energie Atomique
InventorsEdgardo Delfino Carosella, Philippe Moreau, Eliane Gluckman, Marek Kirszenbaum
Life of this patent
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Abstract
Transcripts of the major histocompatibility complex (MHC) Class I HLA-G gene which are present in foetal trophoblasts and/or in adult circulating mono-nuclear cells, as well as methods of using these. Either the said transcripts comprise, in succession in the 5' to 3' direction: a fragment encoding the signal peptide (exon 1), a fragment encoding the .alpha.1 domain (exon 2), a fragment encoding the .alpha.2 domain (exon 3), a fragment encoding the transmembrane TM domain (exon 5), a fragment encoding the cytoplasmic domain (exon 6) and the 3' untranslated fragment (exon 8), which sequence is designated HLA-G4, or the said transcripts comprise intron 4.
Claims21
A protein encoded by a transcript of the human MHC HLA-G gene, wherein said transcript comprises in succession from the 5' end to the 3' end:
- a sequence encoding the .alpha.2 domain;
- a sequence encoding the transmembrane domain;
- and
- a sequence encoding the cytoplasmic domain;
- said transcript not containing a sequence encoding the .alpha.3 domain.
A polypeptide which has the amino acid sequence of SEQ ID NO:7.
A protein encoded by a transcript of the human MHC HLA-G gene, wherein said transcript comprises in succession from the 5' end to the 3' end:
- a sequence encoding the signal peptide;
- a sequence encoding the .alpha.1 domain;
- a sequence encoding the .alpha.3 domain;
- intron 4;
- and
- a sequence encoding the transmembrane domain.
A polypeptide having the amino acid sequence of SEQ ID NO:8.
A polypeptide which has the amino acid sequence of SEQ ID NO:9.
A water soluble protein encoded by a transcript of a human MHC HLA-G gene, wherein said transcript comprises in succession from the 5' end to the 3' end:
- a sequence encoding the signal peptide;
- a sequence encoding the .alpha.1 domain;
- a sequence encoding the .alpha.3 domain, and
- intron 4,
- said transcript not including a sequence encoding the transmembrane domain.
A protein encoded by a transcript of the human MHC HLA-G gene, wherein said transcript comprises in succession from the 5' end to the 3' end:
- a sequence encoding the signal peptide;
- a sequence encoding the .alpha.1 domain;
- a sequence encoding the .alpha.2 domain;
- intron 4;
- a sequence encoding the transmembrane domain;
- a sequence encoding the cytoplasmic domain located on the 3' side of said sequence encoding the transmembrane domain.
Dependencies are inferred from the claim text.