Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof
AssigneeXoma Corporation
InventorRoger G. Little, II
Life of this patent
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Abstract
The present invention provides peptides having an amino acid sequence that is the amino acid sequence of a human bactericidal/permeability-increasing protein (BPI) functional domain or a subsequence thereof, and variants of the sequence or subsequence thereof, having at least one of the BPI biological activities, such as heparin binding, heparin neutralization, LPS binding, LPS neutralization or bactericidal activity. The invention provides peptides and pharmaceutical compositions of such peptides for a variety of therapeutic uses.
Claims11
A peptide which has a 7-35 amino acid sequence of human bactericidal/permeability-increasing protein (BPI) from about position 17 to about position 45 of SEQ ID NO:69, and variants of the sequence having a biological activity that is an activity of BPI.
A peptide which has a 7-35 amino acid sequence of human bactericidal/permeability-increasing protein (BPI) from about position 65 to about position 99 of SEQ ID NO:69, and variants of the sequence having a biological activity that is an activity of BPI.
A peptide which has a 7-35 amino acid sequence of human bactericidal/permeability-increasing protein (BPI) from about position 142 to about position 169 of SEQ ID NO:69, and variants of the sequence having a biological activity that is an activity of BPI.
Dependencies are inferred from the claim text.