Hepatitis C virus isolate polypeptides
AssigneesChiron Corporation, The Director General of the National Institute of Health of Japan
InventorsTatsuo Miyamura, Izumi Saito, Michael Houghton, Amy J. Weiner, Jang Han, Janice A. Kolberg, Tai-An Cha, Bruce D. Irvine
Life of this patent
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Abstract
Two new isolates of the Hepatitis C virus (HCV), J1 and J7, are disclosed. These new isolates comprise nucleotide and amino acid sequences which are distinct from the prototype HCV isolate, HCV1. Thus, J1 and J7 provide new polynucleotides and polypeptides for use, inter alia, in diagnostics, recombinant protein production and vaccine development.
Claims14
An isolated hepatitis C virus polypeptide comprising an antigen comprising a sequence as shown in FIG. 6, FIG. 7, FIG. 8, FIG. 9, FIG. 10, or encoded by a polynucleotide sequence deposited under Accession Numbers BP-2593, BP-2594, BP-2595, BP-2637, or BP-2638, said encoded sequence being in frame with the corresponding amino acid sequences set out in FIG. 6, FIG. 7, FIG. 8, FIG. 9, or FIG. 10, or a fragment thereof, wherein said antigen is not immunologically cross-reactive with HCV-1.
Dependencies are inferred from the claim text.