Thyroxine/cyclodextrin complexes and pharmaceutical compositions containing the same
AssigneeHexal AG
InventorsWilfried Fischer, Daniel Bracher
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Abstract
Thyroxine containing pharmaceutical compositions with improved aqueous solubility, stability and enhanced membrane permeation have been prepared by formulating thyroxine with cyclodextrins. These thyroxine/cyclodextrin complexes can further be transformed into different dosage forms (oral tablets, injectables, transdermal patches, hydrogels, ointments, suppositories etc.) by employing known, common pharmaceutical additives.
Claims16
A transdermal composition comprising a solution or hydrogel of .gamma.-cyclodextrin and a thyroxine selected from the group consisting of L-thyroxine, D-thyroxine, a pharmaceutically acceptable salt of L-thyroxine, a pharmaceutically acceptable salt of D-thyroxine, and mixtures thereof.
Dependencies are inferred from the claim text.