Tachykinin antagonists

A compound of formula ##STR120## or a pharmaceutically acceptable salt thereof wherein R is phenyl or naphthalene each unsubstituted, mono-, di-, or trisubstituted by

• alkyl,
• hydroxy,
• alkoxy,
• NO.sub.2,
• halogen,
• NH.sub.2, or
• CF.sub.3 ;
• R.sup.1 and R.sup.2 are each independently hydrogen or alkyl of from 1 to 4 atoms;
• R and R.sup.2, when joined by a bond, can form a ring;
• X is ##STR121## wherein R.sup.11 is hydrogen or alkyl of from 1 to 3 carbon atoms;
• R.sup.3 is hydrogen or (CH.sub.2).sub.m R.sup.13 where m is an integer of from 1, to 6 and R.sup.13 is H, CN, NH.sub.2, N(CH.sub.3).sub.2, or NHCOCH.sub.3 ;
• n is an integer of from 1 to 2;
• R.sup.8 is phenyl or naphthalene each unsubstituted, or mono-, di-, or trisubstituted by
• alkyl,
• hydroxy,
• alkoxy,
• NO.sub.2,
• halogen,
• NH.sub.2, or
• CF.sub.3 ;
• Y is ##STR122## wherein R.sup.4 is hydrogen or alkyl of from 1 to 3 carbon atoms, --CO.sub.2 --,
• --COCH.sub.2 --,
• --CH.sub.2 O--,
• --CH.sub.2 NH--,
• --CH.dbd.CH--,
• --CH.sub.2 CH.sub.2 --,
• --CHOHCH.sub.2 --;
• R.sup.5 and R.sup.7 are each independently hydrogen or alkyl of from 1 to 4 carbon atoms;
• q is an integer of from 0 to 1;
• and
• R.sup.6 is phenyl or naphthalene each unsubstituted, or mono-, di-, or trisubstituted by
• alkyl,
• hydroxy,
• alkoxy,
• NO.sub.2,
• halogen,
• NH.sub.2, or
• CF.sub.3.