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US 5,856,346 AGranted
Short-acting dihydropyridines
AssigneeAstra Aktiebolag
InventorsKjell Hjalmar Andersson, Margareta Nordlander, Rolf Christer Westerlund
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AssigneeAstra Aktiebolag
InventorsKjell Hjalmar Andersson, Margareta Nordlander, Rolf Christer Westerlund
Estimating the term…
Compounds of the general formula ##STR1## wherein R.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen, chloro, bromo, nitro, cyano, trifluoromethyl, and R.sub.3 and R.sub.4 are independently selected from straight or branched lower (1-5 carbon atoms) alkyl groups, and including all optical isomers, provided that when R.sub.3 is methyl and R.sub.4 is tert.-butyl, then R.sub.1 /R.sub.2 are not hydrogen/hydrogen, hydrogen/2'-trifluormethyl, 2'-chloro/3'-chloro, and when R.sub.3 is methyl and R.sub.1 /R.sub.2 is hydrogen/3'-nitro, then R.sub.4 are not methyl, ethyl, propyl, iso-propyl, tert.-butyl, processes for their preparation, pharmaceutical preparations containing them and the use of the compounds in lowering the blood pressure.
A compound of the formula ##STR12## wherein R.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen, chloro, bromo, nitro, cyano and trifluoromethyl, and R.sub.3 and R.sub.4 are independently selected from the group consisting of straight and branched C.sub.1-5 alkyl groups and including all optical isomers, provided that when R.sub.3 is methyl and R.sub.4 is tert-butyl, then R.sub.1 /R.sub.2 are not hydrogen/hydrogen, hydrogen/ 2'-trifluoromethyl, 2'-chloro/3'-chloro, and when R.sub.3 is methyl and R.sub.2 /R.sub.1 is hydrogen/3'-nitro, then R.sub.4 is not methyl, ethyl, propyl, iso-propyl or tert-butyl or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.