Method for stabilizing pranoprofen and stable liquid preparation of pranoprofen
AssigneesSenju Pharmaceutical Co., Ltd., Yoshitomi Pharmaceutical Industries, Ltd.
InventorsKoji Doi, Hisako Sawa, Yoshie Ozaki, Yoshiyuki Kimura
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Abstract
A method for stabilizing pranoprofen, comprising placing an aqueous solution of pranoprofen in coexistence with an antioxidant, or placing an aqueous solution of pranoprofen under the conditions of limited supply of oxygen, and a stable aqueous preparation of pranoprofen, comprising pranoprofen and an antioxidant. According to the present invention, the decomposition of pranoprofen in an aqueous solution of pranoprofen is remarkably suppressed. In particular, pranoprofen becomes stable to light, thus permitting long-term preservation of an aqueous solution, specifically a liquid preparation, of pranoprofen.
Claims13
A method for stabilizing pranoprofen, comprising adding an antioxidant which is at least one member selected from the group consisting of an alkyl phenol, a benzopyran derivative, sodium thiosulfate and an amino acid, to an aqueous solution of pranoprofen.
A stable liquid preparation of pranoprofen comprising pranoprofen and an antioxidant which is at least one member selected from the group consisting of an alkyl phenol, a benzopyran derivative, sodium thiosulfate and an amino acid.
Dependencies are inferred from the claim text.