Combination of a .beta.-receptor blocker and a local anaesthetic
AssigneeAstra AB
InventorArne Eek
Life of this patent
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Abstract
New combination of a .beta.-receptor blocker, an enantiomer thereof, and a local anesthetic, administered simultaneously or sequentially, giving excellent pain relief. Also comprised in the invention is the use of a non-selective .beta.-receptor blocker alone, especially a non-selective .beta.-receptor blocker giving pain relief.
Claims45
A pharmaceutical composition for achieving essentially complete sensory block in a patient without substantial motor block, comprising a .beta.-receptor blocker and a local anesthetic, wherein:
- a) said .beta.-receptor blocker is present at a concentration sufficient to produce essentially complete sensory block when administered to said patient in combination with said local anesthetic;
- and
- b) said local anesthetic is present at a concentration:
- i) sufficient to produce essentially complete sensory block in said patient when administered in combination with said .beta.-receptor blocker;
- and
- ii) lower than the concentration needed to produce essentially complete sensory block in said patient when said local anesthetic is administered as the sole therapeutically active agent;
- with the proviso that said local anesthetic is not lidocaine.
A method for treating a subject experiencing pain so as to produce essentially complete sensory block in the absence of substantial motor block, said method comprising administering to said patient a .beta.-receptor blocker and a local anesthetic, wherein:
- a) said .beta.-receptor blocker is administered in an amount sufficient to produce essentially complete sensory block in said patient when administered in combination with said local anesthetic;
- b) said local anesthetic is administered:
- i) in an amount sufficient to produce essentially complete sensory block in said patient when administered in combination with said .beta.-receptor blocker;
- ii) in an amount lower than that needed to produce essentially complete sensory block when said local anesthetic is administered as the sole therapeutically active agent;
- and
- iii) with the proviso that said local anesthetic is not lidocaine.
Dependencies are inferred from the claim text.