Substituted aminothienopyridines, pharmaceutical composition and use
AssigneeHoechst Marion Roussel, Inc.
InventorsRichard Charles Effland, Joseph Thomas Klein, Lawrence Leo Martin
Life of this patent
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Abstract
This application relates to compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, m and n are as defined in the specification which are useful as modulators of neurotransmitter function such as serotonergic and adrenergic, and as such are useful as antidepressants, anxiolytics, atypical antipsychotics, antiemetics, and for the treatment of personality disorders such as obsessive compulsive disorders. Certain of the compounds are also useful as glycine partial agonists.
Claims25
A compound of the formula ##STR23## where R.sup.1 is hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.6)alkenyl, (C.sub.3 -C.sub.6)alkynyl, aryl(C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkylcarbonyl, formyl, (C.sub.1 -C.sub.6)alkoxycarbonyl, aryl(C.sub.1 -C.sub.6)alkoxycarbonyl, aryl(C.sub.1 -C.sub.6)alkoxycarbonylamino(C.sub.1 -C.sub.18)alkylcarbonyl, (C.sub.1 -C.sub.6)alkoxycarbonylamino(C.sub.1 -C.sub.18)alkylcarbonyl (C.sub.1 -C.sub.6)alkylamino(C.sub.1 -C.sub.6)alkylcarbonyl, amino(C.sub.1 -C.sub.18)alkylcarbonyl, (C.sub.1 -C.sub.6)dialkylamino(C.sub.1 -C.sub.6)alkylcarbonyl, amino(C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkylamino(C.sub.1 -C.sub.6)alkyl, or (C.sub.1 -C.sub.6)dialkylamino(C.sub.1 -C.sub.6)alkyl;
- R.sup.2 is hydrogen or (C.sub.1 -C.sub.6)alkyl;
- with the proviso that R.sup.1 and
- R.sup.2 are not concurrently hydrogen;
- and
- R.sup.3 is hydrogen, (C.sub.1 -C.sub.6)alkyl or (C.sub.1 -C.sub.6)alkoxycarbonyl;
- n is 0, 1, 2 or 3;
- m is 0, 1, 2 or 3;
- with the proviso that the sum of m and n is always 3;
- and
- pharmaceutically acceptable addition salts thereof and optical or geometrical isomers or racemic mixtures thereof.
Dependencies are inferred from the claim text.