Benzotriazines, pharmaceutical compositions, and methods of using same
AssigneeBoehringer Mannheim GmbH
InventorsWalter-Gunar Friebe, Werner Scheuer, Ulrich Tibes
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AssigneeBoehringer Mannheim GmbH
InventorsWalter-Gunar Friebe, Werner Scheuer, Ulrich Tibes
Estimating the term…
Use of compounds of the formula I ##STR1## in which R.sub.1 signifies an amino, C.sub.1 -C.sub.6 -alkylamino, di-C.sub.1 -C.sub.6 -alkylamino or a hydroxyl group, R.sub.2 and R.sub.3, which are the same or different, each hydrogen, halogen, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy, cyano, carboxyl, halogen-C.sub.1 -C.sub.6 -alkyl, cyano-C.sub.1 -C.sub.6 -alkyl, carboxy-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 - alkyl, hydroxyl, carboxy-C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -alkoxycarbonyl-C.sub.1 -C.sub.6 -alkoxy or aminocarbonyl-C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -alkylaminocarbonyl-C.sub.1 -C.sub.6 -alkoxy or di-C.sub.1 -C.sub.6 -alkylaminocarbonyl-C.sub.1 -C.sub.6 -alkoxy and n the number 0 or 1, their tautomers, as well as salts with non-toxic acids or bases, for the preparation of medicaments with PLA.sub.2 -inhibiting action, new compounds and process for their preparation.
A method of inhibiting PLA.sub.2 in a mammal in need of such inhibition comprising administering to said mammal a PLA.sub.2 inhibiting effective amount of a compound of formula I ##STR5## wherein R.sub.1 is hydroxyl,
A compound of the formula Ia ##STR6## wherein R.sub.2 is in 7- position and is selected from the group consisting of hydrogen, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 - alkoxy, cyano-C.sub.1 -C.sub.6 -alkyl, and hydroxyl;
A method for reducing inflammation by inhibiting PLA.sub.2 in a mammal in need of such inhibition comprising administering to said mammal an inflammation reducing effective amount of a compound of formula I ##STR7## wherein R.sub.1 is hydroxyl,
Dependencies are inferred from the claim text.