Use of dioxomorpholines for combat endoparasites, dioxomorpholines and process for their production
AssigneeBayer Aktiengesellschaft
InventorsAndrew Plant, Jurgen Scherkenbeck, Peter Jeschke, Achim Harder, Norbert Mencke
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Abstract
The present invention relates to the use of dioxomorpholines of the formula (I) ##STR1## in which the radicals R.sup.1 to R.sup.5 have the meanings given in the description, their use for combating endoparasites and new dioxomorpholines and processes for their preparation.
Claims10
A method of combating endoparasites comprising administering to a human or an animal an endoparasiticidally effective amount of at least one dioxomorpholine of the formula (I):
- ##STR51## in which R.sup.1 and R.sup.2 independently of one another represent hydrogen, straight-chain or branched alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl or heteroarylalkyl which are optionally substituted, or
- R.sup.1 and R.sup.2 together represent a spirocycle radical which is optionally substituted,
- R.sup.3 represents hydrogen, straight-chain or branched alkyl, cycloalkyl, aralkyl, aryl, heteroaryl or heteroarylalkyl, which are optionally substituted, or
- R.sup.2 and R.sup.3 together with the atoms to which they are bonded represent a 5- or 6-membered ring, which can optionally be substituted,
- R.sup.4 and R.sup.5 independently of one another represent hydrogen, straight-chain or branched alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl, which are optionally substituted, or
- R.sup.4 and R.sup.5 together represent a spirocyclic radical, which is optionally substituted,
- in the form of a racemic mixture or an optically active isomer thereof.
An endoparasiticidal composition comprising a pharmaceutically acceptable carrier and an endoparasiticidally effective amount of at least one dioxomorpholine of the formula (I):
- ##STR52## in which R.sup.1 and R.sup.2 independently of one another represent hydrogen, straight-chain or branched alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl or heteroarylalkyl which are optionally substituted, or
- R.sup.1 and R.sup.2 together represent a spirocycle radical which is optionally substituted,
- R.sup.3 represents hydrogen, straight-chain or branched alkyl, cycloalkyl, aralkyl, aryl, heteroaryl or heteroarylalkyl, which are optionally substituted, or
- R.sup.2 and R.sup.3 together with the atoms to which they are bonded represent a 5- or 6-membered ring, which can optionally be substituted,
- R.sup.4 and R.sup.5 independently of one another represent hydrogen, straight-chain or branched alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl, which are optionally substituted, or
- R.sup.4 and R.sup.5 together represent a spirocyclic radical, which is optionally substituted,
- in the form of a racemic mixture or an optically active isomer thereof.
Dependencies are inferred from the claim text.