Nitrogen-containing cyclohetero cyclo-heteroaminoaryl derivatives for CNS disorders

A compound of the formula:

• ##STR18## wherein each of R.sup.1, R.sup.4, R.sup.5, R.sup.6, and R.sup.7 is independently selected from hydrido, alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, aryl, alkoxyalkyl, haloalkyl, hydroxyalkyl, carboxy, carboxyalkyl, alkanoyl, alkenyl and alkynyl;
• wherein each of R.sup.2, R.sup.3 and R.sup.8 through R.sup.13 is independently selected from hydrido, hydroxy, alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, aryl, alkoxy, aryloxy, aralkoxy, alkoxyalkyl, haloalkyl, hydroxyalkyl, cyano, amino, monoalkylamino, dialkylamino, carboxy, carboxyalkyl, alkanoyl, alkenyl and alkynyl;
• wherein R.sup.2 and R.sup.3 may be taken together to form oxo or to form a saturated or partially unsaturated carbocyclic group having three to eight ring carbons;
• wherein R.sup.4 and R.sup.5 may be taken together to form oxo, or to form a saturated or partially unsaturated carbocyclic group having three to eight ring carbons;
• wherein R.sup.10 and R.sup.11 may be taken together to form oxo;
• wherein m is four;
• and n and p are integers of from one to four;
• wherein Z is selected from the group consisting of ##STR19## wherein the ring defined by ›C!.sub.n, Z, ›C!.sub.p and N is a seven to eleven member ring;
• wherein R.sup.14 may be selected from hydrido, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, alkanoyl, aralkanoyl, aroyl, aminoalkyl, monoalkylaminoalkyl and dialkylaminoalkyl;
• wherein each of R.sup.15 through R.sup.18 is independently selected from hydrido, hydroxy, alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, aryl, alkoxy, aralkoxy, aryloxy, alkoxyalkyl, haloalkyl, hydroxyalkyl, halo, cyano, amino, monoalkylamino, dialkylamino, carboxy, carboxyalkyl and alkanoyl;
• wherein A is selected from aryl, heteroaryl, aryloxy, heteroaryloxy, aralkoxy, heteroaralkoxy, arylamino, heteroarylamino, aralkylamino, heteroaralkylamino, arylthio, heteroarylthio, aralkylthio and heteroaralkylthio;
• wherein any of the A groups can be further substituted with one or more substituents independently selected from hydrido, hydroxy, alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, aryl, alkoxy, aryloxy, aralkoxy, alkoxyalkyl, halo, haloalkyl, hydroxyalkyl, cyano, amino, monoalkylamino, dialkylamino, carboxy, carboxyalkyl, alkanoyl, alkenyl and alkynyl;
• or a pharmaceutically-acceptable salt thereof.