Methods of treatment
AssigneeHoffmann-La Roche Inc.
InventorsBenoit Thomas Dore, Richard Lewis Momparler, Milan Radoje Uskokovic
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Abstract
A method of inducing inhibition or loss of cell proliferation in solid tumors utilizing a Vitamin D.sub.3 analog, as well as a method of inducing loss of cell proliferation in solid tumors utilizing trans retinoic acid and a Vitamin D.sub.3 analog. In another aspect, a method of inducing inhibition or loss of cell proliferation in solid tumors utilizing a Vitamin D.sub.3 metabolite, as well as a method of inducing loss of cell proliferation in solid tumors utilizing trans retinoic acid and a Vitamin D.sub.3 metabolite.
Claims4
A method of inducing inhibition of cell proliferation in a solid breast tumor which comprises administering to a host in need of such treatment an effective amount of a Vitamin D.sub.3 analog selected from the group consisting of:
- 26,26,26,27,27,27-hexafluoro-1.alpha.,25-dihydroxy-16-ene-23-yne-19-nor-cho lecalciferol;
- 26,26,26,27,27,27-hexafluoro-25-hydroxy-16-ene-23-yne-19-nor-cholecalcifero l;
- and
- 26,26,26,27,27,27-hexafluoro-1.alpha.-fluoro-25-hydroxy-16-ene-23-yne-19-no r-cholecalciferol.
Dependencies are inferred from the claim text.