Methods for inhibiting proliferation of tumor cells and tumor growth
AssigneeAmerican Cyanamid Company
InventorsJoseph M. Backer, Peter Bohlen
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Abstract
The invention relates to a method for inhibiting angiogenesis and proliferation of endothelial cells by administering an inhibitory amount of 7-substituted amino!-9-(substituted glycyl)amido!-6-demethyl-6-deoxytetracycline of Formula I: ##STR1## wherein R, R.sub.2, R.sub.3, and W are as defined in the specification. The invention also relates to a method for inhibiting proliferation of tumor cells and tumor growth by administering an inhibitory amount of a compound of Formula I in combination with a chemotherapeutic agent or radiation therapy. The invention also relates to compositions containing an effective inhibitory amount of a compound of Formula I in a pharmaceutically acceptable carrier.
Claims6
A method for inhibiting tumor cell proliferation and tumor growth which comprises administering an effective inhibitory amount of a compound of formula I:
- ##STR9## wherein R is a (disubstituted) amino of the formula --N(R.sub.4)(R.sub.5) and (R.sub.4)and (R.sub.5) may be the same or different and are selected from straight or branched (C.sub.1 -C.sub.4)alkyl, or (C.sub.3 -C.sub.6)cycloalkyl!(C.sub.1 -C.sub.4)alkyl;
- W is (R.sub.1).sub.2 --N--;
- R.sub.1 --NH-- or (C.sub.2 -C.sub.5)azacycloalkane wherein
- R.sub.1 is a straight chain (C.sub.1 -C.sub.7)alkyl;
- R.sub.2 is hydrogen or (C.sub.1 -C.sub.3)alkyl;
- R.sub.3 is hydrogen or (C.sub.1 -C.sub.3)alkyl;
- or a pharmaceutically acceptable salt thereof;
- in combination with a chemotherapeutic agent or radiation therapy;
- to a warm blooded animal having a disorder characterized by the undesired proliferation of tumor cells.
Dependencies are inferred from the claim text.