Artificial collagen
AssigneeHaemacure Corporation
InventorsSerge St. Pierre, Teresa Brodniewicz
Life of this patent
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Abstract
The invention provides artificial collagen comprising a stabilized ordered triple helix of copolypeptide strands containing repeating amino acid triads. The collagen may be modified with groups which improve its physical or chemical properties for the intended use, such as adhesive and cross-linking groups. Artificial collagen according to the invention is particularly useful as a wound closer and healer.
Claims35
Artificial collagen molecule comprising a water-soluble, stabilized ordered copolypeptide triple-helix characterized by three polypeptide strands of amino acid triads, each strand covalently linked via the C-terminal end thereof to a common template of the formula:
- (POLYMER).sub.w .circle-solid.{(X.sub.aa -X.sub.bb -Gly)-(X.sub.aa -X.sub.bb -Gly).sub.n -(X.sub.aa -X.sub.bb -Gly)-(SPACER).sub.x !.sub.3 -(TEMPLATE)-(AM).sub.y }
- wherein X.sub.aa and X.sub.bb independently of each other are each a hydrophilic or neutral residue of a naturally-occurring amino acid or homolog thereof;
- TEMPLATE is a stabilizing moiety containing at least three functional groups each reacted with the C-terminal end of one polypeptide strand and capable of stabilizing the triple-helix;
- POLYMER is a polymer from about 200 to 100,000 daltons covalently linked at at least one end thereof to functional amino acid residue side chains present in the triple helix or in AM, or at the N-terminal end of each strand of the triple helix;
- AM is a adhesive moiety for promoting cohesiveness of the molecule or adhesiveness of the molecule or both;
- SPACER is a bifunctional linear molecule covalently linked to the C-terminal end of each polypeptide strand and to the template;
- n is from 1 to 28;
- x and y are each independently one or zero;
- and
- w is from 0 to 30;
- each triad is the same or different;
- and at least one of x, y, or w is one or more.
Dependencies are inferred from the claim text.