Peptide, a bronchus-expanding agent, and a blood-flow-improving agent
AssigneeItoham Foods Inc.
InventorsKazuhisa Kashimoto, Yumiko Nagano
Life of this patent
Estimating the term…
Abstract
The present invention relates to a peptide represented by the general formula (1): ##STR1## wherein A is Ala or Gly; B is Ile or Val; C is Asn or Ser; D is Thr or Ser; E is Leu or Tyr; each of F, I and J is Lys or Arg, and at least one of F, I and J is Arg; G is Met, Leu or Nle; K is Asn or Ala; L is Ser or Ala; M is Ile or Val; and N is --NH.sub.2 or Asn--NH.sub.2, excluding the combination where A is Ala, B is Val, C is Asn, D is Thr, E is Leu, K is Asn, L is Ser, M is Ile, and N is Asn--NH.sub.2, and pharmaceutically acceptable salts thereof, as well as to a bronchus-expanding agent or a blood-flow-improving agent comprising said peptide or a pharmaceutically acceptable salt thereof as an active ingredient.
Claims29
A peptide represented by the formula (1):
- ##STR4## wherein B and M are Ile or Val;
- C is Asn or Ser;
- D is Thr or Ser;
- E is Leu or Tyr;
- each of F, I and J is Lys or Arg, and at least one of them is Arg;
- G is selected from the group consisting of Leu, Met, and Nle;
- K is Ala or Asn;
- L is Ala or Ser;
- N is Asn or a chemical bond;
- O is selected from the group consisting of Lys, Arg and the chemical bond;
- and P is selected from the group consisting of Arg--NH.sub.2, Arg--OH, and --NH.sub.2.
A peptide represented by the general formula (12):
- ##STR15## wherein B and M are Ile or Val;
- C is Asn or Ser;
- D is Thr or Ser;
- E is Leu or Tyr;
- each of F, I and J is Lys or Arg, and at least one of them is Arg;
- G is selected from the group consisting of Leu, Met, and Nle;
- K is Ala or Asn;
- L is Ala or Ser;
- N is Asn or a chemical bond;
- O is Gly or the chemical bond;
- P is selected from the group consisting of Lys, Arg, and the chemical bond;
- Q is selected from the group consisting of Arg--NH.sub.2, Arg--OH and --NH.sub.2 ;
- excluding the peptide wherein B is Val, C is Asn, D is Thr, E is Leu, K is Asn, L is Ser, and M is Ile.
Dependencies are inferred from the claim text.