Therapeutic uses of bactericidal/permeability-increasing protein dimer products
AssigneeXoma Corporation
InventorsWilliam Steve Ammons, Roger G. Little
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Abstract
Improved therapeutic compositions, methods and uses of bactericidal/permeability-increasing protein (BPI) products involve use of dimeric forms of BPI protein product monomers characterized by enhanced in vivo biological activity. Preferred formulations include 50 percent or more by weight dimeric product and preferred therapeutic uses include endotoxin neutralization and heparin neutralization.
Claims16
A bactericidal/permeability-increasing protein (BPI) protein product pharmaceutical composition containing greater than 50 percent of a stable dimeric BPI protein product formed by covalent or NotI-covalent linkage of BPI protein product monomers, other than a dimeric BPI protein product formed by the linkage of immunoglobulin portions of BPI-immunoglobulin fusion protein variants, and a pharmaceutically acceptable diluent, adjuvant or carrier, said dimeric BPI protein product characterized by an enhanced in vivo biological activity in comparison to said BPI protein product monomers.
Dependencies are inferred from the claim text.