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AssigneeThomas Jefferson University
InventorsGerald Litwack, Emad S. Alnemri, Teresa Fernandez-Alnemri
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Substantially pure interleukin-1 converting enzyme isoforms are disclosed. Pharmaceutical compositions comprising one or more interleukin-1 converting enzyme isoforms are disclosed. Nucleic acid molecules that encode interleukin-1 converting enzyme isoforms, recombinant expression vectors that comprise a nucleic acid sequence that encodes an interleukin-1 converting enzyme isoform, and host cells that comprise recombinant expression vectors that comprise nucleic acid sequences that encode interleukin-1 converting enzyme isoforms are disclosed. Fragments of nucleic acid molecules with sequences encoding interleukin-1 converting enzyme isoform and oligonucleotide molecules that comprise a nucleotide sequence complimentary to fragment of a nucleotide sequence that encodes an interleukin-1 converting enzyme isoform are disclosed. Antibodies which bind to an epitope on interleukin-1 converting enzyme isoforms are disclosed. Methods of identifying inhibitors of ICE isoforms are disclosed.
An isolated nucleic acid molecule consisting of a nucleotide sequence selected from the group consisting of:
A recombinant expression vector comprising a nucleic acid sequence that encodes the protein having an amino acid sequence selected from the group consisting of:
An isolated nucleic acid molecule according to claim 8 consisting of SEQ ID NO:3.
An isolated nucleic acid molecule consisting of up to a total of 50 nucleotides including a nucleotide sequence selected from the group consisting of SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO;24 and SEQ ID NO:25.
An isolated nucleic acid molecule consisting of up to a total of 100 nucleotides including a nucleotide sequence of SEQ ID NO:22. therein said nucleic acid molecule is a fragment of a nucleic acid molecule having SEQ ID NO:3.
An isolated nucleic acid molecule consisting of up to a total of 50 nucleotides including a nucleotide sequence of SEQ ID NO:22, wherein said nucleic acid molecule is a fragment of a nucleic acid molecule having SEQ ID No:3.
An isolated nucleic acid molecule consisting of up to a total of 100 nucleotides including a nucleotide sequence of SEQ ID NO:23, wherein said nucleic acid molecule is a fragment of a nucleic acid molecule having SEQ ID NO:5.
An isolated nucleic acid molecule of up to a total of 50 nucleotides including a nucleotide sequence selected from the group consisting of SEQ ID NO:23, wherein said nucleic acid molecule is a fragment of a nucleic acid molecule having SEQ ID NO:5.
An isolated nucleic acid molecule consisting of up to a total of 100 nucleotides including a nucleotide sequence of SEQ ID NO:24, wherein said nucleic acid molecule is a fragment of a nucleic acid molecule having SEQ ID NO:7.
An isolated nucleic acid molecule consisting of up to a total of 50 nucleotides including a nucleotide sequence of SEQ ID NO:24, wherein said nucleic acid molecule is a fragment of a nucleic acid molecule having SEQ ID NO:7.
An isolated nucleic acid molecule consisting of up to a total of 100 nucleotides including a nucleotide sequence of SEQ ID NO:25, wherein said nucleic acid molecule is a fragment of a nucleic acid molecule having SEQ ID NO:9.
The isolated nucleic acid molecule consisting of up to a total of 50 nucleotides including a nucleotide sequence of SEQ ID NO:25, wherein said nucleic acid molecule is a fragment of a nucleic acid molecule having SEQ ID NO:9.
An isolated nucleic acid molecule consisting of up to a total of 100 nucleotides including a nucleotide sequence of SEQ ID NO:22.
An isolated nucleic acid molecule consisting of up to a total of 100 nucleotides including a nucleotide sequence of SEQ ID NO:23.
An isolated nucleic acid molecule consisting of up to a total of 58 nucleotides including a nucleotide sequence of SEQ ID NO:24.
An isolated nucleic acid molecule consisting of up to a total of 100 nucleotides including a nucleotide sequence of SEQ ID NO:25.
A PCR primer of up to 58 nucleotides comprising a nucleotide sequence identical or complementary to a nucleotide sequence of SEQ ID NO:24.
A PCR primer of up to 100 nucleotides comprising a nucleotide sequence identical or complementary to a nucleotide sequence selected from the group consisting of SEQ ID NO:22, SEQ ID NO:23 and SEO ID NO:25.
Dependencies are inferred from the claim text.