Nucleic acids encoding and recombinant production of the .beta. subunit of lutenizing hormone
AssigneeGenzyme Corporation
InventorsVermuri B. Reddy, Nancy Hsiung, Anton K. Beck, Edward George Berstine
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Abstract
Biologically active heterodimeric human fertility hormones composed of two different subunits, each subunit being synthesized in the same cell transformed by at least one cell expression vector having heterologous DNA encoding each subunit with each subunit being controlled by a separate promoter. Preferred human fertility hormones include hCG, hLH and hFSH.
Claims4
Isolated DNA encoding the .beta.-subunit of human luteinizing hormone and having the sequence encoding said human luteinizing hormone which is present in E. coli clone pCL28XhoLHBVP (ATCC 39475).
An expression vector containing DNA encoding the .beta.-subunit of human luteinizing hormone and having the sequence encoding said human luteinizing hormone which is present in E. coli clone pCL28XhoLHBVP (ATCC 39475).
Dependencies are inferred from the claim text.