Detection of a leptin receptor variant
AssigneeProgenitor, Inc.
InventorsH. Ralph Snodgrass, Joseph Cioffi, Thomas Joel Zupancic, Alan Wayne Shafer
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Abstract
The present invention relates to a variant form of the receptor for the obese gene product. In particular, the invention relates to methods of detecting this receptor variant in cells and tissues of obese individuals. In addition, it relates to methods of inhibiting or down-regulating expression of this variant in cells to augment their responsiveness to weight regulation by leptin as well as methods of using compounds to directly activate signal transduction pathways associated with this ligand-receptor system.
Claims19
A method for detecting a nucleic acid encoding a leptin receptor variant in a cell, comprising:
- (a) contacting a nucleic acid molecule derived from the cell with a polynucleotide selected from the group consisting of
- (i) nucleotides #2770 through #2991 of SEQ ID NO:1;
- (ii) the complement of the polynucleotide of (i);
- (iii) a portion of the polynucleotide of (i) that specifically hybridizes to a nucleic acid comprising the polynucleotide of (ii);
- and
- (iv) a portion of the polynucleotide of (ii) that specifically hybridizes to a nucleic acid comprising the polynucleotide of (i);
- and
- (b) detecting hybridization of the polynucleotide with the nucleic acid molecule.
Dependencies are inferred from the claim text.