Bioactive conjugates of cellulose with amino compounds
AssigneeBar-Ilan University
InventorsShlomo Margel, Sophia Sturchak
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AssigneeBar-Ilan University
InventorsShlomo Margel, Sophia Sturchak
Estimating the term…
Polymers containing a plurality of free hydroxy groups, such as cellulose, agarose or polyvinyl alcohol, are contacted in absence of reactants for hydroxy groups, with at least one N-heterocyclic compound, e.g. pyridine, pyrrole, pyridazine, their partially or fully hydrogenated analogs and any of these which may be substituted, in a pre-activation step prior to reaction with reactant for free hydroxy groups in the polymer, the polymer-bound residue of which reactant may be thereafter reacted in turn with amino compounds containing at least one unsubstituted N-attached hydrogen atom, e.g. proteins, thereby to form amine-polymer conjugates. The invention further relates to a powder, bandage, patch or like cover for application to wounds which has been manufactured from polymer containing a plurality of hydroxy groups by a process which includes the step of providing an amine conjugated to the polymer; the amine may be, e.g., trypsin, chymotrypsin, lysozyme, collagenase, albumin and hyaluronidase.
A textile web bandage, patch or like bandage, patch or like wound cover derived from a polymer composition comprising at least one member selected from the group consisting of cellulose, polysaccharides other than cellulose and polyvinyl alcohol and its copolymers which contain a plurality of free hydroxy groups, which said at least one member has been subjected to preactivation by treatment with at least one N-heterocyclic compound for a period of time sufficient to increase the capacity of said at least one member for reaction with a reactant;
Dependencies are inferred from the claim text.